2006 Southern Football Schedule
| Date | Opponent | Time |
| Sept. 2 | Southern 30, Bethune-Cookman 29 |
W, 1-0 |
| Sept. 9 | * SOUTHERN 31, MISS. VALLEY STATE 14 |
W, 2-0, 1-0 |
| Sept. 16 | * Prairie View 26, Southern 23 (OT) |
L, 2-1, 1-1 |
| Sept. 23 | N.C. CENTRAL 27, SOUTHERN 20 |
L, 2-2 |
| Sept. 30 | * SOUTHERN 38, ALABAMA STATE 20 |
W, 3-2, 2-1 |
| Oct. 7 | * Alabama A&M 28, Southern 21 |
L, 3-3, 2-2 |
| Oct. 14 | * Jackson State 31, Southern 28 |
L, 3-4, 2-3 |
| Oct. 21 | * Alcorn State 26, Southern 10 |
L, 3-5, 2-4 |
| Oct. 28 | Open Date | -- |
| Nov. 4 | * SOUTHERN 34, TEXAS SOUTHERN 17 |
W, 4-5, 3-4 |
| Nov. 11 | * ARKANSAS-PINE BLUFF 45, SOUTHERN 20 |
L, 4-6, 3-5 |
| Nov. 18 | Open Date | -- |
| Nov. 25 | * Southern 21, Grambling 17 | W, 5-6, 4-5 |
| * SWAC games | ||
| HOME GAMES IN ALL CAPS | ||